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Safety and efficacy of l-histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80172 for all animal species

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al. EFSA J. .

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-histidine monohydrochloride (HCl) monohydrate produced by fermentation using Corynebacterium glutamicum KCCM 80172 when used as a nutritional additive in feed and water for drinking for all animal species. The production strain is genetically modified. The production strain and its recombinant DNA were not detected in the final product. l-Histidine HCl monohydrate manufactured by fermentation using C. glutamicum KCCM 80172 does not give rise to any safety concern regarding the genetic modification. The use of l-histidine HCl monohydrate produced by fermentation using C. glutamicum KCCM 80172 is safe for the target species when used as a nutritional additive to supplement the diet in appropriate amounts to cover the requirements, depending on the species, the physiological state of the animal, the performance level, the environmental conditions, the background amino acid composition of the unsupplemented diet and the status of some essential trace elements such as copper and zinc. l-Histidine HCl monohydrate produced using C. glutamicum KCCM 80172 supplemented at levels appropriate for the requirements of the target species is considered safe for the consumer. l-Histidine HCl monohydrate produced using C. glutamicum KCCM 80172 is not irritant to skin, is a mildly irritant to eyes, and it is not a skin sensitiser. The additive does not pose a risk to users by inhalation. The use of l-histidine HCl monohydrate produced by C. glutamicum KCCM 80172 in animal nutrition is not expected to represent a risk to the environment. l-Histidine HCl monohydrate is considered an efficacious source of the essential amino acid l-histidine for non-ruminant animal species. For the supplemental l-histidine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.

Keywords: Corynebacterium glutamicum KCCM 80172; amino acid; feed additive; l‐histidine monohydrochloride monohydrate; nutritional additive; safety.

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Figures

Figure 1
Figure 1
Molecular structure of l‐histidine monohydrochloride monohydrate
See this image and copyright information in PMC

References

    1. Ahmed I, 2013. Dietary amino acid l‐histidine requirement of fingerling Indian catfish, Heteropneustes fossilis (Bloch), estimated by growth and whole body protein and fat composition. Journal of Ichthyology, 29, 602–609.
    1. Ahrens FA, 1967. Histamine, lactic acid and hypertonicity as factors in the development of rumenitis in cattle. American Journal of Veterinary Research, 28, 1335–1342. - PubMed
    1. An H and Ben‐Bigirey B, 1998. Scombrotoxin poisoning In: Millar I, Gray D. and Strachan N. (eds.). Microbiology of Seafoods. Chapman Hall Ltd, London: pp. 68–69.
    1. Aoyama Y and Kato C, 2000. Suppressive effect of excess dietary histidine on the expression of hepatic metallothionein‐1 in rats. Bioscience Biotechnology Biochemistry, 64, 588–591. - PubMed
    1. Aoyama Y, Kato C and Sakakibara S, 2001. Expression of metallothionein in the liver and kidney of rats is influenced by excess dietary histidine. Comparative Biochemistry and Pathology Part C, 128, 339–347. - PubMed