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Case Reports
. 2020 Jun 28;12(6):e8877.
doi: 10.7759/cureus.8877.

A Rare Case of Melorheostosis in the Hand of a Saudi Woman

Abdulaziz H Abed  1 , Hosam T Mashrah  2 , Akeel M Almahdaly  3 , Mahmood Shaheen  4
Affiliations
Case Reports

A Rare Case of Melorheostosis in the Hand of a Saudi Woman

Abdulaziz H Abed et al. Cureus. .

Abstract

Melorheostosis is a very rare bone dysplasia, especially in the hand. Most cases were diagnosed incidentally, with the lower limbs being the most affected. This is the first Saudi woman with hand melorheostosis. A 33-year-old Saudi female had mild to moderate right-hand pain that started six years ago. Hand examination showed a full range of motion and full hand grip, and there was no tenderness upon palpation. Plain X-ray, unenhanced CT scan, and MRI of the hand showed an appearance resembling dripping candle wax as melorheostosis. The bone scan showed a nonvascular and nonacute lesion. An unenhanced CT scan demonstrated cortical and endosteal hyperostosis involving the proximal, middle, and distal third and fourth phalanges. Multi-sequential MRI of the hand demonstrated cortical hyperostosis involving the ulnar and radial aspect of the right fourth proximal, middle, and distal phalanges. Features in the X-ray, CT scan, bone scan, and MRI confirmed a diagnosis of melorheostosis with associated flexor tenosynovitis.

Keywords: case; leri’s disease; melorheostosis; rare.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Plain X-ray: A - Bilateral hands. B - Right hand.
Figure 2
Figure 2. Bone scan of the hands.
Figure 3
Figure 3. CT scan of the right hand.
Figure 4
Figure 4. MRI of the right hand.
A) T1-Weighted MRI. B) T2-Weighted MRI.
See this image and copyright information in PMC

References

    1. Melorheostosis in the pediatric hand. Farr S. https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.2160. Clin Case Rep. 2019;7:1110–1111. - PMC - PubMed
    1. Soft tissue contractures from melorheostosis involving the upper extremity. Pruitt DL, Manske PR. https://pubmed.ncbi.nlm.nih.gov/1538118/ J Hand Surg Am. 1992;17:90–93. - PubMed
    1. Craniofacial melorheostosis. McDermott M, Branstetter 4th BF, Seethala RR. https://pubmed.ncbi.nlm.nih.gov/18830120/ J Comput Assist Tomogr. 2008;32:825–827. - PubMed
    1. Loss-of-function mutations in LEMD3 result in osteopoikilosis. Buschke-Ollendorff syndrome and melorheostosis. Hellemans J, Preobrazhenska O, Willaert A, et al. https://www.nature.com/articles/ng1453?draft=collection. Nat Genet. 2004;36:1213–1218. - PubMed
    1. Melorheostosis and osteopoikilosis: a review of clinical features and pathogenesis. Wordsworth P, Chan M. https://www.nature.com/articles/ng1453. Calcif Tissue Int. 2019;104:530–543. - PubMed

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