Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2020 Nov;43(11):1309-1317.
doi: 10.1111/pace.14004. Epub 2020 Jul 24.

Implantable cardiac defibrillator leads dysfunction after LVAD implantation

Vincent Galand  1 , Christophe Leclercq  1 , Hamed Bourenane  1 , Stéphane Boulé  2 , André Vincentelli  2 , Philippe Maury  3 , Pierre Mondoly  3 , François Picard  4 , Nicolas Welté  4 , Michel Kindo  5 , Thomas Cardi  5 , Jean-Luc Pasquié  6 , Philippe Gaudard  7 , Jean-Baptiste Gourraud  8 , Vincent Probst  8 , Pascal Defaye  9 , Aude Boignard  9 , Marylou Para  10 , Vincent Algalarrondo  10 , Edeline Pelcé  11 , Vlad Gariboldi  11 , Matteo Pozzi  12 , Jean-François Obadia  12 , Frédéric Anselme  13 , Pierre-Yves Litzler  13 , Katrien Blanchart  14 , Gerard Babatasi  14 , Fabien Garnier  15 , Marie Bielefeld  15 , David Hamon  16 , Nicolas Lellouche  16 , Thierry Bourguignon  17 , Bertrand Pierre  17 , Romain Eschalier  18 , Nicolas D'Ostrevy  18 , Emilie Varlet  19 , Eloi Marijon  19 , Hugues Blangy  20 , Nicolas Sadoul  20 , Erwan Flécher  1 , Raphaël P Martins  1
Affiliations
Observational Study

Implantable cardiac defibrillator leads dysfunction after LVAD implantation

Vincent Galand et al. Pacing Clin Electrophysiol. 2020 Nov.

Abstract

Background: Implantable cardioverter-defibrillator (ICD) lead dysfunction has been reported after left ventricular assist device (LVAD) implantation in limited single-center studies. We aimed at describing and characterizing the incidence of ICD lead parameters dysfunction after LVAD implantation.

Methods: Among the 652 patients enrolled in the ASSIST-ICD study, only patients with an ICD prior to LVAD were included (n = 401). ICD lead parameters dysfunction following LVAD implantation is defined as follows: (a) >50% decrease in sensing threshold, (b) pacing lead impedance increase/decrease by >100Ω, and (c) >50% increase in pacing threshold.

Results: One hundred twenty-two patients with an ICD prior to LVAD had available ICD interrogation reports prior and after LVAD. A total of 67 (55%) patients exhibited at least one significant lead dysfunction: 17 (15%) exhibited >50% decrease in right ventricular (RV) sensing, 51 (42%) had >100 Ω increase/decrease in RV pacing impedance, and 24 (20%) experienced >50% increase in RV pacing threshold. A total of 52 patients experienced ventricular arrhythmia during follow-up and all were successfully detected and treated by the device. All lead dysfunction could be managed conservatively.

Conclusion: More than 50% of LVAD-recipients may experience >1 significant change in lead parameters but none had severe clinical consequences.

Keywords: implantable cardioverter defibrillator; lead parameters dysfunction; left ventricular assist device.

PubMed Disclaimer

References

REFERENCES

    1. Foo D, Walker BD, Kuchar DL, et al. Left ventricular mechanical assist devices and cardiac device interactions: an observational case series. Pacing Clin Electrophysiol. 2009;32:879-887.
    1. Ambardekar AV, Lowery CM, Allen LA, et al. Effect of left ventricular assist device placement on preexisting implantable cardioverter-defibrillator leads. J Card Fail. 2010;16:327-331.
    1. Boudghène-Stambouli F, Boulé S, Goéminne C, et al. Clinical implications of left ventricular assist device implantation in patients with an implantable cardioverter-defibrillator. J Interv Card Electrophysiol. 2014;39:177-184.
    1. Thomas IC, Cork DP, Levy A, et al. ICD lead parameters, performance, and adverse events following continuous-flow LVAD implantation. Pacing Clin Electrophysiol. 2014;37:464-472.
    1. Hu YL, Kasirajan V, Tang DG, et al. Prospective evaluation of implantable cardioverter-defibrillator lead function during and after left ventricular assist device implantation. JACC Clin Electrophysiol. 2016;2:343-354.

Publication types

LinkOut - more resources