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. 2020 Jul;16(7):1078-1094.
doi: 10.1002/alz.12123. Epub 2020 Jul 5.

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

Miia Kivipelto  1   2   3   4   5 , Francesca Mangialasche  1   6 , Heather M Snyder  7 , Ricardo Allegri  8 , Sandrine Andrieu  9   10 , Hidenori Arai  11 , Laura Baker  12 , Sylvie Belleville  13 , Henry Brodaty  14 , Sonia M Brucki  15 , Ismael Calandri  8 , Paulo Caramelli  16 , Christopher Chen  17   18 , Howard Chertkow  19   20 , Effie Chew  21 , Seong H Choi  22 , Neerja Chowdhary  23 , Lucía Crivelli  8 , Rafael De La Torre  24 , Yifeng Du  25 , Tarun Dua  23 , Mark Espeland  12   26 , Howard H Feldman  27   28 , Maris Hartmanis  1   29 , Tobias Hartmann  30 , Megan Heffernan  14 , Christiani J Henry  31 , Chang H Hong  32 , Krister Håkansson  1   3 , Takeshi Iwatsubo  33   34 , Jee H Jeong  35 , Gustavo Jimenez-Maggiora  36 , Edward H Koo  37 , Lenore J Launer  38 , Jenni Lehtisalo  39   40 , Francisco Lopera  41 , Pablo Martínez-Lage  42 , Ralph Martins  43   44 , Lefkos Middleton  5   45 , José L Molinuevo  46 , Manuel Montero-Odasso  47 , So Y Moon  48 , Kristal Morales-Pérez  1   29 , Ricardo Nitrini  15 , Haakon B Nygaard  28 , Yoo K Park  49 , Markku Peltonen  1   39 , Chengxuan Qiu  6   25 , Yakeel T Quiroz  41   50 , Rema Raman  36 , Naren Rao  51 , Vijayalakshmi Ravindranath  52 , Anna Rosenberg  40 , Takashi Sakurai  11 , Rosa M Salinas  53 , Philip Scheltens  54 , Gustavo Sevlever  8 , Hilkka Soininen  40 , Ana L Sosa  53 , Claudia K Suemoto  55 , Mikel Tainta-Cuezva  42   56 , Lina Velilla  41 , Yongxiang Wang  25 , Rachel Whitmer  57 , Xin Xu  17   18 , Lisa J Bain  58 , Alina Solomon  1   40 , Tiia Ngandu  1   39 , Maria C Carrillo  7
Affiliations

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

Miia Kivipelto et al. Alzheimers Dement. 2020 Jul.

Abstract

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Keywords: Alzheimer's disease; World-Wide FINGERS; cognitive impairment; dementia; lifestyle; multidomain intervention; prevention; randomized controlled trial.

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Conflict of interest statement

CONFLICTS OF INTEREST

Maria C. Carrillo and Heather M. Snyder are full-time employees of the Alzheimer’s Association. Henry Brodaty (MYB) is on the Advisory Board for Nutricia Australia. Rafael De la Torre and José L. Molinuevo are full-time employees of the Hospital del Mar Medical Research Institute and the Barcelonabeta Brain Research Institute, respectively. All the other co-authors declare no conflicts of interest in connection with this work.

Figures

FIGURE 1
FIGURE 1
World map with countries that are involved in the World-Wide FINGERS Network. Dark blue indicates involvement in ongoing World-Wide FINGERS studies. Studies are currently planned in countries marked with light blue
FIGURE 2
FIGURE 2
Levels defined for the trials participating in the World-Wide FINGERS Network
See this image and copyright information in PMC

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