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Review
. 2020 Aug 28;30(8):1109-1115.
doi: 10.4014/jmb.2006.06006.

Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses

Kyun-Do Kim  1 , Insu Hwang  1 , Keun Bon Ku  1 , Sumin Lee  1 , Seong-Jun Kim  1 , Chonsaeng Kim  1
Affiliations
Review

Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses

Kyun-Do Kim et al. J Microbiol Biotechnol. .

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response against SARS-CoV-2 infection needs to be understood for the development of an efficient and safe vaccine. Here, we review the current understanding of vaccine targets and the status of vaccine development for COVID-19. We also describe host immune responses to highly pathogenic human coronaviruses in terms of innate and adaptive immunities.

Keywords: COVID-19; Coronavirus; SARS-CoV-2; immune response; vaccine.

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Conflict of interest statement

Conflict of Interest

The authors have no financial conflicts of interest to declare.

Figures

Fig. 1
Fig. 1. The innate and adaptive immune responses to COVID-19.
Immune responses to human coronaviruses are summarized. Newly reported immune response to SARS-CoV-2 is highlighted in red.
See this image and copyright information in PMC

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