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. 2020 Jul 17;22(14):5337-5341.
doi: 10.1021/acs.orglett.0c01584. Epub 2020 Jul 6.

Formicins, N-Acetylcysteamine-Bearing Indenone Thioesters from a Wood Ant-Associated Bacterium

Young Eun Du  1 , Woong Sub Byun  1 , Seok Beom Lee  2 , Sunghoon Hwang  1 , Yern-Hyerk Shin  1 , Bora Shin  1 , Yong-Joon Jang  3 , Suckchang Hong  2 , Jongheon Shin  1 , Sang Kook Lee  1 , Dong-Chan Oh  1
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Formicins, N-Acetylcysteamine-Bearing Indenone Thioesters from a Wood Ant-Associated Bacterium

Young Eun Du et al. Org Lett. .

Abstract

Formicins A-C (1-3) were discovered from Streptomyces sp. associated with wood ants. The structures of 1 and 2 were elucidated as indenone thioesters bearing N-acetylcysteamine based on spectroscopic analysis. The configurations of 1-3 were determined by the analysis of ROESY correlations, the phenylglycine methyl ester method, and chemical derivatization from 3 to 2. Formicin A inhibited the growth of human triple-negative breast cancer cells by regulating the liver kinase B1-mediated AMPK signaling pathway.

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