Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Oct 1;202(7):915-917.
doi: 10.1164/rccm.202005-2004ED.

Emerging Complexity in the Biomarkers of Exacerbation-Prone Asthma

Peter J Sterk  1 , Anirban Sinha  1   2
Affiliations
Editorial

Emerging Complexity in the Biomarkers of Exacerbation-Prone Asthma

Peter J Sterk et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic showing the fundamental complexity of biology in asthma and the need for composite biomarkers to predict exacerbation risk. Conventional statistical approaches need to be supplemented with artificial intelligence and longitudinal time-series analyses to capture its informational organization, complex interactions, and dynamics for optimization of prediction models.
See this image and copyright information in PMC

Comment on

References

    1. Loijmans RJB, Gemperli A, Cohen J, Rubinstein SM, Sterk PJ, Reddel HK, et al. Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis. BMJ. 2014;348:g3009. - PMC - PubMed
    1. Kim CK, Callaway Z, Gern JE. Viral infections and associated factors that promote acute exacerbations of asthma. Allergy Asthma Immunol Res. 2018;10:12–17. - PMC - PubMed
    1. Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, et al. NHLBI Severe Asthma Research Program. Evidence for exacerbation-prone asthma and predictive biomarkers of exacerbation frequency. Am J Respir Crit Care Med. 2020;202:973–982. - PMC - PubMed
    1. ten Brinke A, Sterk PJ, Masclee AA, Spinhoven P, Schmidt JT, Zwinderman AH, et al. Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur Respir J. 2005;26:812–818. - PubMed
    1. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, et al. National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med. 2017;195:302–313. [Published erratum appears in Am J Respir Crit Care Med 197:971.] - PMC - PubMed