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. 2020 Jul 6;20(1):230.
doi: 10.1186/s12877-020-01622-8.

Nocturia in patients with cognitive dysfunction: a systematic review of the literature

Rebecca Haddad  1   2 , Thomas F Monaghan  3   4 , Charles Joussain  5   6 , Véronique Phé  7 , Wendy Bower  8 , Saskia Roggeman  3 , Gilberte Robain  9 , Karel Everaert  3
Affiliations

Nocturia in patients with cognitive dysfunction: a systematic review of the literature

Rebecca Haddad et al. BMC Geriatr. .

Abstract

Background: The objective of this study is to evaluate current literature on the association between cognitive dysfunction and nocturia.

Methods: A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was conducted through MEDLINE, EMBASE and COCHRANE databases and completed in November 2019. Randomized and non-randomized studies were included if they assessed the association between cognitive dysfunction and nocturia in older participants with or without neurological diseases. The quality of included studies was evaluated using the Risk of Bias Assessment tool for Non-randomized Studies (RoBANS).

Results: A total of 8 cross-sectional studies conducted in older patient populations met the criteria for inclusion. A statistically significant association was identified in 6 studies on univariate analysis, which persisted in 2 studies after controlling for confounding factors. The association between cognitive dysfunction and nocturia was positive for all 6 significant analyses. The overall risk of bias was unclear.

Conclusion: A significant positive association between cognitive dysfunction and nocturia was identified. However, research has been limited to cross-sectional studies, which precludes identification of causality between cognitive dysfunction and nocturia. Heightened awareness of the complex interplay between cognition and nocturia would allow professionals involved in the care of cognitively impaired patients with concomitant nocturia to more effectively manage these symptoms.

Keywords: Cognitive dysfunction; Epidemiology; Lower urinary tract symptoms; Nocturia; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram
Fig. 2
Fig. 2
Risk of bias in included studies. 2A. Risk of bias summary: review authors’ judgements about each risk of bias item for each included study. 2B. Risk of bias graph: review authors’ judgements about each risk of bias item presented as percentages across all included studies.?: unclear risk of bias; −: high risk of bias; +: low risk of bias
Fig. 3
Fig. 3
Hypotheses for the association between cognitive dysfunction and nocturia. CNS: central nervous system; OAB: overactive bladder.
See this image and copyright information in PMC

Comment in

References

    1. Andersson F, Anderson P, Holm-Larsen T, Piercy J, Everaert K, Holbrook T. Assessing the impact of nocturia on health-related quality-of-life and utility: results of an observational survey in adults. J Med Econ. 2016;19:1200–1206. doi: 10.1080/13696998.2016.1211136. - DOI - PubMed
    1. Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V, et al. International continence society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. Neurourol Urodyn. 2019;38(2):499–508. - PubMed
    1. Bosch JLHR, Weiss JP. The prevalence and causes of nocturia. J Urol. 2013;189(1 Suppl):S86–S92. - PubMed
    1. Endeshaw YW, Schwartz AV, Stone K, Caserotti P, Harris T, Smagula S, et al. Nocturia, insomnia symptoms and mortality among older men: the health, aging and body composition study. J Clin Sleep Med. 2016;12:789–796. doi: 10.5664/jcsm.5870. - DOI - PMC - PubMed
    1. Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK. Nocturia and disturbed sleep in the elderly. Sleep Med. 2009;10:540–548. doi: 10.1016/j.sleep.2008.04.002. - DOI - PMC - PubMed

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