doi: 10.1002/art.1780311011.
Effects of recombinant human interleukin-1 beta on rabbit articular chondrocytes. Stimulation of prostanoid release and inhibition of cell growth
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- PMID: 3263134
- DOI: 10.1002/art.1780311011
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Effects of recombinant human interleukin-1 beta on rabbit articular chondrocytes. Stimulation of prostanoid release and inhibition of cell growth
Arthritis Rheum.
1988 Oct.
Abstract
Using an in vitro model, we characterized the production of prostaglandin E2, 6-keto-prostaglandin F1 alpha, and thromboxane B2 by normal rabbit articular chondrocytes stimulated by interleukin-1 beta. The prostanoids were produced in a dose- and time-dependent manner, which was sensitive to actinomycin D and cycloheximide. Interleukin-1 also had a pronounced, but reversible, cytostatic effect on chondrocytes, which was not attributable to prostanoid or polyamine synthesis.
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