AK2 deficiency: An awkward tale for B cells

Affiliations

¹ Division of Metabolism, Experimental Medicine Research Cluster (EMRC) and Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, Campinas State University, Campinas, Brazil.
² Division of Metabolism, Experimental Medicine Research Cluster (EMRC) and Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, Campinas State University, Campinas, Brazil. Electronic address: pmvieira@unicamp.br.

Editorial

Ana Campos Codo et al. J Allergy Clin Immunol. 2020 Jul.

. 2020 Jul;146(1):74-76.

doi: 10.1016/j.jaci.2020.04.060.

¹ Division of Metabolism, Experimental Medicine Research Cluster (EMRC) and Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, Campinas State University, Campinas, Brazil.
² Division of Metabolism, Experimental Medicine Research Cluster (EMRC) and Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, Campinas State University, Campinas, Brazil. Electronic address: pmvieira@unicamp.br.

No abstract available

Keywords: AK2; B cells; adenylate kinase 2; common variable immunodeficiency; immunometabolism; reticular dysgenesis.

Comment on

Hypomorphic variants in AK2 reveal the contribution of mitochondrial function to B-cell activation.
Chou J, Alazami AM, Jaber F, Hoyos-Bachiloglu R, Jones J, Weeks S, Alosaimi MF, Bainter W, Cangemi B, Badran YR, Mohammed R, Alroqi F, Almutairi A, Al-Onazi N, AlAjaji S, Al-Saud B, Arnaout R, Elkins M, Devana S, Imperial J, Li B, Drexhage L, Abdel Rahman AM, Jacob M, Haddad H, Hanna-Wakim R, Dbaibo G, Massaad MJ, Dasouki M, Mikhael R, Baz Z, Geha RS, Al-Mousa H. Chou J, et al. J Allergy Clin Immunol. 2020 Jul;146(1):192-202. doi: 10.1016/j.jaci.2019.12.004. Epub 2019 Dec 17. J Allergy Clin Immunol. 2020. PMID: 31862378 Clinical Trial.