Sjögren Syndrome and Cancer

Ann Igoe¹, Sali Merjanah², R Hal Scofield³

Affiliations

¹ Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA.
² The Metrohealth System, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
³ Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; US Department of Veterans Affairs, Oklahoma City, OK, USA. Electronic address: hal-scofield@omrf.ouhsc.edu.

PMID: 32631601
DOI: 10.1016/j.rdc.2020.05.004

Review

Sjögren Syndrome and Cancer

Ann Igoe et al. Rheum Dis Clin North Am. 2020 Aug.

. 2020 Aug;46(3):513-532.

doi: 10.1016/j.rdc.2020.05.004.

Authors

Ann Igoe¹, Sali Merjanah², R Hal Scofield³

Affiliations

¹ Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA.
² The Metrohealth System, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
³ Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; US Department of Veterans Affairs, Oklahoma City, OK, USA. Electronic address: hal-scofield@omrf.ouhsc.edu.

PMID: 32631601
DOI: 10.1016/j.rdc.2020.05.004

Abstract

The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients. This article discusses the accumulating data on various malignancies described in primary Sjögren syndrome, highlighting non-Hodgkin lymphoma and thyroid, multiple myeloma, and skin cancers. These reported associations may have clinical implications in daily practice and contribute to understanding of both autoimmunity and cancer.

Keywords: Amyloidosis; Autoimmune disease; Lymphoma; Lymphoproliferative disorders; Malignancy; Salivary glands; Sjögren syndrome.

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Conflict of interest statement

Disclosure The authors have no commercial or financial conflicts of interest. This work was supported in part by NIH grants AR053483, AI0822714, and GM104938.

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Sjögren Syndrome and Cancer

Affiliations

Sjögren Syndrome and Cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical