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Review
. 2020 Aug;46(3):587-603.
doi: 10.1016/j.rdc.2020.04.003. Epub 2020 Jun 7.

Immune Checkpoint Inhibition-Does It Cause Rheumatic Diseases? Mechanisms of Cancer-Associated Loss of Tolerance and Pathogenesis of Autoimmunity

Uma Thanarajasingam  1 , Noha Abdel-Wahab  2
Affiliations
Review

Immune Checkpoint Inhibition-Does It Cause Rheumatic Diseases? Mechanisms of Cancer-Associated Loss of Tolerance and Pathogenesis of Autoimmunity

Uma Thanarajasingam et al. Rheum Dis Clin North Am. 2020 Aug.

Abstract

Mechanisms of immune checkpoints and their role in autoimmunity are discussed in the context of immune checkpoint inhibitor (ICI) therapy for cancer. The updated clinical spectrum of immune-related adverse events (irAEs), with an in-depth discussion of rheumatic irAEs, is presented. The relationship between ICI-induced loss of self-tolerance in cancer and the implications for understanding of irAEs, rheumatic irAEs in particular, is overviewed.

Keywords: Autoimmunity; Immune checkpoint inhibitors; Immune-related adverse events; Rheumatic diseases; Tolerance.

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Conflict of interest statement

Disclosure Dr. Thanarajasingam is supported by the “Catalyst” award for Advancing in Academics Program, funded by the Department of Medicine, Mayo Clinic, Rochester, MN.

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