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Editorial
. 2021 Feb;161(2):e228-e230.
doi: 10.1016/j.jtcvs.2020.05.087. Epub 2020 Jun 6.

Commentary: Evolving understanding of coronavirus disease 2019: Molecular biology, immunology, and surgery

Edward Buratto  1 , Igor E Konstantinov  2
Affiliations
Editorial

Commentary: Evolving understanding of coronavirus disease 2019: Molecular biology, immunology, and surgery

Edward Buratto et al. J Thorac Cardiovasc Surg. 2021 Feb.
No abstract available

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Figures

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Edward Buratto, MBBS, PhD, and Igor E. Konstantinov, MD, PhD, FRACS
Figure 1
Figure 1
Pathophysiology of coronavirus 2019 (COVID-19) disease. Coronavirus enters cells by binding to angiotensin-converting enzyme 2 (ACE2). Resultant decreased ACE2 availability translates into activation of the angiotensin signaling that causes increased vascular permeability, which, in its turn, facilitates extravasation of mononuclear cells and neutrophils leading to a generalized endotheliitis in response to ongoing viral infection. A cytokine storm in susceptible individuals contributes to further progression of diseases from moderate to severe. CO2, Carbon dioxide; O2, oxygen; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; ARB, angiotensin receptor blocker.
See this image and copyright information in PMC

Comment on

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