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Review
. 2020 Aug 20;64(9):e01101-20.
doi: 10.1128/AAC.01101-20. Print 2020 Aug 20.

Clinical Trials of Repurposed Antivirals for SARS-CoV-2

Miguel Angel Martinez  1
Affiliations
Review

Clinical Trials of Repurposed Antivirals for SARS-CoV-2

Miguel Angel Martinez. Antimicrob Agents Chemother. .

Abstract

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted the repurposing of drugs on the basis of promising in vitro and therapeutic results with other human coronavirus diseases, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). These repurposed drugs have mainly included remdesivir, favipiravir, lopinavir-ritonavir, ribavirin, interferons, and hydroxychloroquine. Unfortunately, the first open-label, randomized, controlled trials are showing poor efficacy of these repurposed drugs. These results highlight the necessity of identifying and characterizing specific and potent SARS-CoV-2 antivirals.

Keywords: COVID-19; SARS-CoV-2; antivirals.

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