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Comment
. 2020 Sep 24;56(3):2001618.
doi: 10.1183/13993003.01618-2020. Print 2020 Sep.

Similarities between COVID-19 and anti-MDA5 syndrome: what can we learn for better care?

Margherita Giannini  1 , Mickael Ohana  2 , Benoit Nespola  3 , Giovanni Zanframundo  4   5 , Bernard Geny  1   6 , Alain Meyer  7   6   8
Affiliations
Comment

Similarities between COVID-19 and anti-MDA5 syndrome: what can we learn for better care?

Margherita Giannini et al. Eur Respir J. .

Abstract

Similarities between COVID-19 and anti-MDA5 syndrome support further evaluation of employing an immunomodulatory strategy in COVID-19 https://bit.ly/3dN6lJ8

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Conflict of interest statement

Conflict of interest: M. Giannini has nothing to disclose. Conflict of interest: M. Ohana has nothing to disclose. Conflict of interest: B. Nespola has nothing to disclose. Conflict of interest: G. Zanframundo has nothing to disclose. Conflict of interest: B. Geny has nothing to disclose. Conflict of interest: A. Meyer has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
a) Clinical and biological features of anti-MDA5 syndrome. b) Cytokines whose levels are increased in anti-MDA5 syndrome patients' serum. c) High-resolution computed tomography of an anti-MDA5 syndrome patient, showing bilateral peripheral subpleural ground-glass opacities prevailing in the lower lobes (arrows), with limited consolidation (arrowheads). ILD: interstitial lung disease; ARDS: acute respiratory distress syndrome; CRP: C-reactive protein; CK: creatine kinase; TNF-α: tumour necrosis factor-α; IL: interleukin; s-IL-2R: soluble IL-2 receptor; IFN-I: interferon type I.
See this image and copyright information in PMC

Comment on

  • COVID-19: consider cytokine storm syndromes and immunosuppression.
    Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; HLH Across Speciality Collaboration, UK. Mehta P, et al. Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16. Lancet. 2020. PMID: 32192578 Free PMC article. No abstract available.

References

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Supplementary concepts