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. 1988;12(1-6):277-82.

Is T-cell activation an unfavourable sign in i.v.-drug addicts infected with HIV?

D N Fuchs  1 , A Hausen, P Hengster, G J Reibnegger, B Unterweger, E R Werner, H Hinterhuber, M P Dierich, H Wachter
Affiliations
  • PMID: 3263196

Is T-cell activation an unfavourable sign in i.v.-drug addicts infected with HIV?

D N Fuchs et al. Cancer Detect Prev. 1988.

Abstract

In a longitudinal study, we examined 183 parenteral drug addicts who were imprisoned in Innsbruck, Austria, from March 1985 to March 1987. Thirty-seven percent of the patients had anti-HIV-antibodies. A 2-year follow-up of 43 seropositive patients revealed some evidence that urinary neopterin levels are of predictive value. Neopterin is produced from human macrophages upon stimulation with interferon gamma and, therefore, represents a sensitive parameter of activated T-cells. Eight patients who developed AIDS-related complex and one of them who contracted AIDS had significantly higher neopterin levels during the previous follow-up than the other groups of patients. Our data support the view that T-cell activation might be a crucial event in the induction of HIV reproduction in vivo.

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