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. 2020 Jul 28;117(30):17513-17515.
doi: 10.1073/pnas.2008373117. Epub 2020 Jul 6.

The implications of silent transmission for the control of COVID-19 outbreaks

Seyed M Moghadas  1 , Meagan C Fitzpatrick  2   3 , Pratha Sah  2 , Abhishek Pandey  2 , Affan Shoukat  2 , Burton H Singer  4 , Alison P Galvani  5
Affiliations

The implications of silent transmission for the control of COVID-19 outbreaks

Seyed M Moghadas et al. Proc Natl Acad Sci U S A. .

Abstract

Since the emergence of coronavirus disease 2019 (COVID-19), unprecedented movement restrictions and social distancing measures have been implemented worldwide. The socioeconomic repercussions have fueled calls to lift these measures. In the absence of population-wide restrictions, isolation of infected individuals is key to curtailing transmission. However, the effectiveness of symptom-based isolation in preventing a resurgence depends on the extent of presymptomatic and asymptomatic transmission. We evaluate the contribution of presymptomatic and asymptomatic transmission based on recent individual-level data regarding infectiousness prior to symptom onset and the asymptomatic proportion among all infections. We found that the majority of incidences may be attributable to silent transmission from a combination of the presymptomatic stage and asymptomatic infections. Consequently, even if all symptomatic cases are isolated, a vast outbreak may nonetheless unfold. We further quantified the effect of isolating silent infections in addition to symptomatic cases, finding that over one-third of silent infections must be isolated to suppress a future outbreak below 1% of the population. Our results indicate that symptom-based isolation must be supplemented by rapid contact tracing and testing that identifies asymptomatic and presymptomatic cases, in order to safely lift current restrictions and minimize the risk of resurgence.

Keywords: COVID-19; case isolation; contact tracing.

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Attack rates when the proportion of infections that are asymptomatic is (A) 17.9% and (B) 30.8%, for scenarios of case isolation including none (yellow), all severe cases (red), and all symptomatic cases (blue). Bars indicate the proportion of attack rate attributable to transmission in different stages of infections. (C) Attack rate when a percentage of silent (i.e., presymptomatic and asymptomatic) infections are detected and isolated in addition to immediate isolation of both mild and severe symptomatic cases.
See this image and copyright information in PMC

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