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Comment
. 2020 Jul;52(7):642-643.
doi: 10.1038/s41588-020-0660-z.

Navigating the path to distant metastasis

Trevor A Graham  1   2 , Darryl Shibata  3   4
Affiliations
Comment

Navigating the path to distant metastasis

Trevor A Graham et al. Nat Genet. 2020 Jul.

Abstract

How ‘difficult’ is it for somatic evolution to produce a cell that is capable of leaving the primary tumor and growing in a distant organ? In this issue, Reiter et al. assess genetic diversity across metastatic lesions and identify a tight selective bottleneck preceding distant metastasis.

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

Figures

Fig. 1 |
Fig. 1 |. Selective bottlenecks in metastasis.
Multiple distinct tumor clones metastasize to lymph nodes (orange, yellow, light- and dark-blue clones), whereas distant metastases are dominated by a single clone (cyan). Analysis of the between-metastasis genetic diversity suggests a narrower selective bottleneck during distant metastasis formation.
See this image and copyright information in PMC

Comment on

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