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. 2020 Sep;34(5):1690-1706.
doi: 10.1111/jvim.15816. Epub 2020 Jul 7.

Bovine viral diarrhea virus: An updated American College of Veterinary Internal Medicine consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination

Paul H Walz  1 , Manuel F Chamorro  1 , Shollie M Falkenberg  2 , Thomas Passler  1 , Frank van der Meer  3 , Amelia R Woolums  4
Affiliations

Bovine viral diarrhea virus: An updated American College of Veterinary Internal Medicine consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination

Paul H Walz et al. J Vet Intern Med. 2020 Sep.

Abstract

Control of bovine viral diarrhea virus (BVDV) in cattle populations across most of the world has remained elusive in spite of advances in knowledge about this viral pathogen. A central feature of virus perseverance in cattle herds is the unique mechanism of persistent infection. Managing BVDV infection in herds involves controlling persistently infected carrier animals using a multidimensional approach of vaccination, biosecurity, and identification of BVDV reservoirs. A decade has passed since the original American College of Veterinary Internal Medicine consensus statement on BVDV. While much has remained the same with respect to clinical signs of disease, pathogenesis of infection including persistent infection, and diagnosis, scientific articles published since 2010 have led to a greater understanding of difficulties associated with control of BVDV. This consensus statement update on BVDV presents greater focus on topics currently relevant to the biology and control of this viral pathogen of cattle, including changes in virus subpopulations, infection in heterologous hosts, immunosuppression, and vaccination.

Keywords: bovine viral diarrhea; immunosuppression; vaccination; viral persistence.

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Conflict of interest statement

Paul H. Walz receives research funding from Zoetis Animal Health and Merck Animal Health. Amelia Woolums consults for and receives research funding from Bayer Animal Health, Boehringer Ingelheim Vetmedica, Merial, Merck Animal Health, and Zoetis Animal Health. Manuel F. Chamorro, Shollie M. Falkenberg, Thomas Passler and Frank van der Meer have no declared conflicts of interest.

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