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. 2021 Dec;35(23):5160-5165.
doi: 10.1080/14786419.2020.1788556. Epub 2020 Jul 7.

Anti-inflammatory activity of a new compound from Vernonia amygdalina

Thi Xuan Thu Nguyen  1 , Duc Long Dang  2 , Van Quang Ngo  3 , Tat Cuong Trinh  4 , Quang Nam Trinh  4   5 , Trung Dong Do  6 , Thi Thu Thuy Thanh  3
Affiliations

Anti-inflammatory activity of a new compound from Vernonia amygdalina

Thi Xuan Thu Nguyen et al. Nat Prod Res. 2021 Dec.

Abstract

In this study, a new stigmastane, vernonioside V, was isolated from the ethanol extract of leaves of Vernonia amygdalina along with a known flavonoid, cynaroside, and then anti-inflammatory activity of isolated compounds was investigated. The result showed that vernonioside V at concentration of 30 µg/mL strongly inhibited TNFα, IL-6, and IL-8 inflammatory cytokine production. Furthermore, LPS-induced supreoxide generation in Raw 264.7 were significantly reduced by pre-treatment of vernonioside V (30 µg/mL). These data indicated that vernonioside V had inhibitory activities on pro-inflammatory cytokine in LPS-stimulated Raw 264.7 through reactive oxygen species (ROS).

Keywords: Vernonia amygdalina; anti-inflammatory activity; reactive oxygen species; vernonioside V.

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