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Comment
. 2021 Jan;93(1):168-169.
doi: 10.1002/jmv.26266. Epub 2020 Jul 14.

A retrospective review of memantine use and COVID-19-associated mortality from a national database

Moon Ho Park  1 , Do Young Kwon  1
Affiliations
Comment

A retrospective review of memantine use and COVID-19-associated mortality from a national database

Moon Ho Park et al. J Med Virol. 2021 Jan.
No abstract available

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Likelihood of mortality in patients with confirmed coronavirus disease 2019 according to treatment with memantine. Univariate and multivariable logistic regressions were used to estimate odds ratio and 95% confidence intervals (CIs). Univariate logistic regression did not adjust any confounder. Multivariable logistic regression model 1 adjusted for age and sex. Multivariable logistic regression model 2 adjusted for age, sex, and comorbidities (hypertension, heart failure, chronic kidney disease, chronic lung disease, diabetes mellitus, dyslipidemia, cancer, stroke, Parkinson's disease, epilepsy, and dementia) at admission. The analysis variables for this study were presented in Supporting Information Table
See this image and copyright information in PMC

Comment on

References

    1. Brenner SR. The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID‐19, including ARDS and to reduce viral replication through lysosomal effects [published online ahead of print May 21, 2020]. J Med Virol. 2020. 10.1002/jmv.26030 - DOI - PMC - PubMed
    1. Cimolai N. Potentially repurposing adamantanes for COVID‐19. J Med Virol. 2020;92:531‐532. 10.1002/jmv.25752 - DOI - PubMed
    1. Honegger UE, Quack G, Wiesmann UN. Evidence for lysosomotropism of memantine in cultured human cells: cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and beta‐adrenergic transmission. Pharmacol Toxicol. 1993;73:202‐208. 10.1111/j.1600-0773.1993.tb01564.x - DOI - PubMed
    1. Rejdak K, Grieb P. Adamantanes might be protective from COVID‐19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment. Multiple Sclerosis and Related Disorders. 2020;42:102163. 10.1016/j.msard.2020.102163 - DOI - PMC - PubMed
    1. World Health Organization . Coronavirus disease 2019 (COVID‐19): situation report, 46, 2020. https://apps.who.int/iris/handle/10665/331443. Accessed June 21, 2020.