Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun 8:10:2155179018773758.
doi: 10.1177/2155179018773758. eCollection 2018.

3-D retina organoids: Building platforms for therapies of the future

Jessica N Mazerik  1 , Steven Becker  1 , Paul A Sieving  1
Affiliations

3-D retina organoids: Building platforms for therapies of the future

Jessica N Mazerik et al. Cell Med. .

Abstract

Across scientific disciplines, 3-D organoid culture systems offer platforms to integrate basic research findings with clinical care. The National Eye Institute mounted a $1.1 million 3-D Retina Organoid Challenge. Organoids developed through the Challenge will be valuable resources for drug screening, disease modeling, and precision and regenerative medicine.

Keywords: Retina; drug screening; organoid; precision medicine; regenerative medicine; stem cells.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Basic research programs will continue to support technology generation, discovery, and translation in the regenerative medicine space. Scientific advances coming out of programs like the NEI Audacious Goals Initiative, the NEI 3-D Retina Organoid Challenge, and NCATS Tissue Chip programs will lay the foundation for translation of cell therapies into clinical trials such as those supported by the California Institute of Regenerative Medicine (CIRM) and the National Institutes of Health (NIH). NAM: National Academy of Medicine.
See this image and copyright information in PMC

References

    1. Bartfeld S, Clevers H. Stem cell-derived organoids and their application for medical research and patient treatment. J Mol Med 2017; 95(7): 729–738. - PubMed
    1. Meyer JS, Howden SE, Wallace KA, et al. Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells 2011; 29(8): 1206–1218. - PMC - PubMed
    1. Eiraku M, Takata N, Ishibashi H, et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 2011; 472(7341): 51–56. - PubMed
    1. Nakano T, Ando S, Takata N, et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 2012; 10(6): 771–785. - PubMed
    1. Capowski EE, Simonett JM, Clark EM, et al. Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation. Hum Mol Genet 2014; 23(23): 6332–6344. - PMC - PubMed