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Meta-Analysis
. 2020 Oct:53:101636.
doi: 10.1016/j.mcp.2020.101636. Epub 2020 Jul 4.

Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review

Raheleh Torabi  1 , Reza Ranjbar  2 , Mehrdad Halaji  3 , Mohammad Heiat  4
Affiliations
Meta-Analysis

Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review

Raheleh Torabi et al. Mol Cell Probes. 2020 Oct.

Abstract

The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.

Keywords: Aptamer; COVID-19; Coronavirus; MERS; Probe; SARS; SARS-CoV-2; Therapy.

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Figures

Fig. 1
Fig. 1
Flow diagram of study selection.
Fig. 2
Fig. 2
Secondary structures of diagnostic Coronaviruses aptamers. a) The secondary structures of different RNA (14), b and c) DNA [16,18] were predicted using the MFold program or permitted previous studies. The variable regions are marked with different colors.
Fig. 3
Fig. 3
Secondary structures of therapeutic Coronaviruses aptamers. a) The secondary structures of different ssDNA aptamer [23] were predicted using the MFold program. b) The AG-rich conserved sequences (Highlighted Regions) at the loop region in RNA aptamer pools, isolated by Jang et al., are assumed as binding motif structure to SARS-CoV RNA helicase [24].
See this image and copyright information in PMC

References

    1. Syed A. Coronavirus: a mini-review. Int. J. Curr. Res. Med. Sci. 2020;6(1):8–10.
    1. Sohrabi C., Alsafi Z., O'Neill N., Khan M., Kerwan A., Al-Jabir A., Iosifidis C., Agha R. World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19) Int. J. Surg. 2020;76:71–76. - PMC - PubMed
    1. Pang J., Wang M.X., Ang I.Y.H., Tan S.H.X., Lewis R.F., Chen J.I., Gutierrez R.A., Gwee S.X.W., Chua P.E.Y., Yang Q., Ng X.Y., Yap R.K., Tan H.Y., Teo Y.Y., Tan C.C., Cook A.R., Yap J.C., Hsu L.Y. Potential rapid diagnostics, vaccine and therapeutics for 2019 novel coronavirus (2019-nCoV): a systematic review. J. Clin. Med. 2020;9(3):623–655. - PMC - PubMed
    1. Hashemzadeh M.S., Rasouli R., Zahraei B., Izadi M., Tat M., Saadat S.H., Najarasl M., Khansari Nejad B., Dorostkar R. Development of dual TaqMan based one-step rRT-PCR assay panel for rapid and accurate diagnostic test of MERS-CoV: a novel human coronavirus, ahead of hajj pilgrimage. Iran. Red Crescent Med. J. 2016;18(11) - PMC - PubMed
    1. Corman V.M., Landt O., Kaiser M., Molenkamp R., Meijer A., Chu D.K., Bleicker T., Brünink S., Schneider J., Schmidt M.L., Mulders D.G., Haagmans B.L., van der Veer B., van den Brink S., Wijsman L., Goderski G., Romette J.-L., Ellis J., Zambon M., Peiris M., Goossens H., Reusken C., Koopmans M.P., Drosten C. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25(3):2000045. - PMC - PubMed

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