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. 2020 Sep:495:108071.
doi: 10.1016/j.carres.2020.108071. Epub 2020 Jun 26.

Synthesis of C6-substituted UDP-GlcNAc derivatives

Zachary A Morrison  1 , Mark Nitz  2
Affiliations

Synthesis of C6-substituted UDP-GlcNAc derivatives

Zachary A Morrison et al. Carbohydr Res. 2020 Sep.

Abstract

UDP-sugar analogs are useful for the study of glycosyltransferases and the production of unnatural glycans. The preparation of five UDP-GlcNAc derivatives is reported with 6-deoxy, 6-azido, 6-amino, 6-mercapto, or 6-fluoro substitutions. A concise chemoenzymatic synthesis was developed using the kinase NahK (B. longum JCM1217) and the uridyl transferase GlmU (E. coli K12).

Keywords: Chemoenzymatic synthesis; GlmU; NahK; UDP-GlcNAc.

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