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. 2020 Jul 3;9(7):2099.
doi: 10.3390/jcm9072099.

Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation

Aleksandra Saletra-Bielińska  1 , Katarzyna Kosińska-Kaczyńska  1   2 , Iwona Szymusik  1 , Bartosz Kaczyński  3 , Robert Brawura-Biskupski-Samaha  1 , Szymon Kozłowski  4 , Patrycja Jarmużek  1 , Izabela Walasik  5 , Mirosław Wielgoś  1
Affiliations

Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation

Aleksandra Saletra-Bielińska et al. J Clin Med. .

Abstract

In twin gestation, the relationship between pregnancy associated plasma protein (PAPP-A) and perinatal outcome is unclear. The aim of the study was to determine if low and high concentrations of PAPP-A in the first trimester are related to perinatal outcome in twins. A retrospective study was conducted. Medical data of women in twin pregnancies who delivered between 2013 and 2018 were analyzed. PAPP-A concentrations were measured between 10 + 0 and 13 + 6 weeks. The associations between low (<10th percentile) and high (>90th percentile) values of PAPP-A and pregnancy complications were analyzed. A total of 304 patients were included. PAPP-A <10th percentile was associated with a high risk of preterm delivery (OR 6.14; 95% CI 2.1-18), delivery <34 weeks (OR 2.39; 95% CI 1.1-5.1) or <32 weeks (OR3.06; 95% CI 1.4-6.8). Significant relations between PAPP-A >90th percentile and delivery <34 weeks (OR4.09; 95% CI 1.8-9.1) or <32 weeks (OR 2.83; 95% CI 1.2-6.6) were found. PAPP-A >90th percentile was related to high risk of intrauterine fetal demise (OR 10; 95% CI 2.4-42.5). Both low and high PAPP-A concentrations seem to be related to pregnancy outcome. Further research is needed to investigate evaluation of risk of pregnancy complications according to PAPP-A concentrations as a continuous variable.

Keywords: intrauterine fetal demise; perinatal outcome; pregnancy associated plasma protein; preterm delivery; twin pregnancy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Generalized additive models of associations between PAPP-A concentration and preterm delivery (PTD) (a), delivery before 34 weeks (b) and delivery before 32 weeks of gestation (c) visualized as spline functions. (a): linear effect p < 0.001, non-linear effect p = 0.08; (b): linear effect p < 0.001, non-linear effect p < 0.001; (c): linear effect p < 0.001, non-linear effect p < 0.001. Vertical axis shows response values of logit (binomial) smooth spline function (“s” with name of the covariate, degrees of value). The bars in the bottoms of the figures present number of samples at each PAPP-A multiples of median (MoM) value.
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