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. 1988 Nov;85(21):8161-5.
doi: 10.1073/pnas.85.21.8161.

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region

M Iwashima  1 , A Green, M M Davis, Y H Chien
Affiliations

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region

M Iwashima et al. Proc Natl Acad Sci U S A. 1988 Nov.

Abstract

A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.

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References

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