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Review
. 2020 Aug;20(8):457-458.
doi: 10.1038/s41577-020-0389-z.

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

Alessandro Sette  1   2 , Shane Crotty  3   4
Affiliations
Review

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

Alessandro Sette et al. Nat Rev Immunol. 2020 Aug.

Erratum in

Abstract

T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses.

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Conflict of interest statement

A.S. is a consultant for Gritstone, Flow Pharma and Avalia. S.C. declares no competing interests.

References

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