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Review
. 2020 Jun 30:14:1805-1832.
doi: 10.2147/OPTH.S178348. eCollection 2020.

XEN® Gel Stent: A Comprehensive Review on Its Use as a Treatment Option for Refractory Glaucoma

Antonio M Fea  1 , Georges M Durr  2   3 , Paola Marolo  1 , Lorenza Malinverni  1 , Mario A Economou  4 , Ike Ahmed  5
Affiliations
Review

XEN® Gel Stent: A Comprehensive Review on Its Use as a Treatment Option for Refractory Glaucoma

Antonio M Fea et al. Clin Ophthalmol. .

Abstract

The XEN Gel Microstent is a subconjunctival microinvasive glaucoma surgical device developed with the aim of improving the predictability and safety profile of bleb-forming glaucoma surgical procedures. The stent is a hydrophilic tube composed of a porcine gel cross-linked with glutaraldehyde with good stability and biocompatibility with minimal tissue reaction. This device has demonstrated promising outcomes with fewer risks compared to traditional surgeries. The aim of the review is to present early studies on different designs of the XEN Gel Stent, to summarize different surgical techniques of implantation and to analyze more comprehensively the results, complications and rates of needling of the commercially available device (Xen 45). The review will address separately special cases (PXG, UVG, ICE, congenital glaucoma) and describe small series and case reports.

Keywords: XEN Gel Stent; efficacy; glaucoma surgery; needling; review; safety.

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Conflict of interest statement

Dr Antonio M Fea reports Consultant fees from Glaukos, Ivantis, ELTSight, iSTAR, and EyeD, travel fess from Johnson and Johnson, Allergan, and Sooft, outside the submitted work. Dr Georges M Durr report personal fees from Alcon, Allergan, Bausch & Lomb, Glaukos, Novartis, MST, Santen, and Sight Sciences, outside the submitted work. Dr Ike Ahmed reports the following, C- Consultant/Consulting Fees S- Speakers Honoraria R- Research Grant/Support; Aequus: C, Aerie Pharmaceuticals: C, R, Akorn: C, Alcon: C,S,R, Allergan: C,S,R, ArcScan: C, Bausch Health: C, Beaver Visitec: C, Beyeonics: C, Camras Vision: C, R, Carl Zeiss Meditec: C,S, CorNeat Vision: C, Ellex: C, ELT Sight: C, ElutiMed: C, Equinox: C, Genentech: C, Glaukos: C, R, Gore: C, InjectSense: C, Iridex: C, iStar: C, Ivantis: C, R, Johnson & Johnson Vision: C, S, R, KeLoTec: C, LayerBio: C, Leica Microsystems: C, MicroOptx: C, MST Surgical: C, S, Mundipharma: S, Mynosys: C, New World Medical: C, R, Ocular Instruments: C, Ocular Therapeutix: C, Omega Ophthalmics: C, PolyActiva: C, Sanoculis: C, Santen: C, R, Science Based Health: C, Sight Sciences: C, Stroma: C, Thea Pharma: C, ViaLase: C, Vizzario: C. The authors report no other conflicts of interest in this work.

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