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. 2020 Jun 19:11:909.
doi: 10.3389/fphar.2020.00909. eCollection 2020.

Danhong Injection for the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

YiZhuo Li  1 , Shihai Yan  1 , Lichao Qian  1 , Lihua Wu  1 , Yawei Zheng  1 , Zhuyuan Fang  2
Affiliations

Danhong Injection for the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

YiZhuo Li et al. Front Pharmacol. .

Abstract

Objective: Danhong Injection (DHI) has been widely used to treat various diseases in China for many years. The objective of this systematic review was to evaluate the efficacy of DHI combined with antihypertensive drugs for treatment of hypertensive nephropathy.

Methods: Seven databases were searched from inception to September 21st, 2019. Randomized controlled trials comparing DHI combined with antihypertensive drugs versus antihypertensive drugs alone were extracted. The primary outcome was microalbuminuria (mALB). Secondary outcomes included systolic blood pressure (SBP), diastolic blood pressure (DBP), and serum creatinine (SCr).

Results: Fifteen studies were included in the meta-analysis, which indicated that DHI combined with antihypertensive drugs has advantages compared with antihypertensive drugs alone for reducing mALB [weighted mean difference (WMD) = -12.86, 95% confidence interval (CI) (-14.72, -11.0), P < 0.01], lowering SBP [WMD = -2.84, 95% CI (-4.56, -1.12), P = 0.001] and DBP [WMD = -2.38, 95% CI (-4.34, -0.43), P = 0.017], and decreasing SCr [WMD = -40.45, 95% CI (-55.69, -25.21), P < 0.01].

Conclusion: The combination of DHI with antihypertensive drugs appears to be more effective than antihypertensive drugs alone for treatment of hypertensive nephropathy. A moderate duration (≤4 weeks) of DHI administration is reasonable, and longer treatment with DHI should be avoided, according to the results of subgroup analysis.

Keywords: Danhong injection; hypertensive nephropathy; meta-analysis; systematic review; traditional Chinese medicine.

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Figures

Figure 1
Figure 1
PRISMA 2009 Flow Diagram.
Figure 2
Figure 2
Risk of bias summary.
Figure 3
Figure 3
Forrest plot of mALB.
Figure 4
Figure 4
Funnel plot for publication bias of mALB.
Figure 5
Figure 5
Subgroup analysis of mALB.
Figure 6
Figure 6
Forrest plot of SB.
Figure 7
Figure 7
Subgroup analysis of SBP.
Figure 8
Figure 8
Forrest plot of DBP.
Figure 9
Figure 9
Subgroup analysis of DBP.
Figure 10
Figure 10
Forrest plot of Scr.
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References

    1. Bakris G. L. (2004). Clinical importance of microalbuminuria in diabetes and hypertension. Curr. Hypertens. Rep. 6, 352–356. 10.1007/s11906-004-0053-1 - DOI - PubMed
    1. Baobao L. (2017). Observation on the effect of trimetazidine combined with Danhong Injection on hypertensive nephropathy. Modern J. Integrated Traditional Chin. Western Med. 26, 1113–1114. 10.3969/j.issn.1008-8849.2017.10.032 - DOI
    1. Binjun Y., Zhengtai G., Haibin Q., Buchang Z., Tao Z. (2013). An approach to determine critical process parameters for ethanol precipitation process of Danhong injection. China J. Chin. Materia Med. 38, 1672–1675. 10.4268/cjcmm20131105 - DOI - PubMed
    1. Changan H., Meiyu Z. (2008). Danhong Injection was used to treat 52 aged patients with hypertensive renal damage. Zhejiang J. Traditional Chin. Med. 43, 59. 10.3969/j.issn.0411-8421.2008.01.043 - DOI
    1. Changjiang L. (2015). Observation on the curative effect of combined traditional Chinese and western medicine on hypertensive renal damage in elderly patients. Northern Pharm. 12, 195. 10.3969/j.issn.1674-6805.2012.05.036 - DOI

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