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Review
. 2020 Feb 20;6(3):131-136.
doi: 10.1016/j.ijwd.2020.02.003. eCollection 2020 Jun.

Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancy

Shashank Bhargava  1 , Ujjwal Kumar  1 , George Kroumpouzos  2   3   4
Affiliations
Review

Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancy

Shashank Bhargava et al. Int J Womens Dermatol. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] Int J Womens Dermatol. 2021 Sep 28;7(5Part B):867. doi: 10.1016/j.ijwd.2021.09.013. eCollection 2021 Dec. Int J Womens Dermatol. 2021. PMID: 35028405 Free PMC article.

Abstract

Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, relapsing, sterile pustular eruption of unknown etiology that develops most commonly in middle-aged or mature women. This article reviews the presentation, associations, and management of the condition and highlights advances in pathophysiology. Onset of SPD during pregnancy has not been reported. Herein, we report a case of SPD that developed during pregnancy. The patient was treated with dapsone without complications for her or the fetus. An association between T helper (Th) 17 and Th2 environments in the development of SPD has been advocated. Pregnancy is characterized by a predominance of Th2 responses and increased interleukin-17 levels and thus may favor the development of the condition.

Keywords: Dapsone; Gestation; Neutrophilic dermatosis; Pregnancy; Sneddon-Wilkinson disease; Subcorneal pustular dermatosis.

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Figures

Fig. 1
Fig. 1
(A) Crusted erythematous plaques with superimposed pustules on the back, as well as discrete, isolated, pea-sized pustules. (B) Closeup view of minute pustules at the rim of round or annular, scaly, erythematous plaques on the forearm.
Fig. 2
Fig. 2
Immediately below a normal stratum corneum is a blister cavity containing numerous neutrophils. The epidermis below the blister shows sparse neutrophils in transit and mild intercellular edema (spongiosis). Lesional skin adjacent to the pustule shows intact granular layer. Dermis shows a neutrophil and lymphocytic infiltrate (hematoxylin and eosin, 10×).
See this image and copyright information in PMC

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