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Clinical Trial
. 1988 Oct;26(4):399-402.
doi: 10.1111/j.1365-2125.1988.tb03397.x.

Comparative effects of fluoxetine and amitriptyline on cardiac function

J W Upward  1 , J G Edwards, A Goldie, D G Waller
Affiliations
Clinical Trial

Comparative effects of fluoxetine and amitriptyline on cardiac function

J W Upward et al. Br J Clin Pharmacol. 1988 Oct.

Abstract

1. The effects of fluoxetine and amitriptyline on the electrocardiogram (ECG) and systolic time intervals (STIs) were measured during a double-blind parallel-group study in depressed patients. 2. ECGs and STIs were measured after a 1 week placebo run-in, following 1 week's treatment with fluoxetine 40 mg daily or amitriptyline 100 mg daily, and then after 3 weeks' treatment with fluoxetine 60-80 mg daily or amitriptyline 150-200 mg daily. 3. Fluoxetine had no effect on the ECG or STIs at any dose. Amitriptyline 150-200 mg daily shortened the sinus cycle length by a mean of 12%, prolonged the PR interval by 8% and the QRS duration by 10%. Amitriptyline did not significantly alter the STIs.

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