Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;114(6):995-1003.
doi: 10.36660/abc.20190879. Epub 2020 Jun 29.

One year follow-up Assessment of Patients Included in the Brazilian Registry of Acute Coronary Syndromes (ACCEPT)

[Article in English, Portuguese]
Pedro Gabriel Melo de Barros E Silva  1 , Otavio Berwanger  2 , Elizabete Silva Dos Santos  3 , Antônio Carlos Sobral Sousa  4 , Margaret Assad Cavalcante  5 , Pedro Beraldo de Andrade  6 , Fernando Carvalho Neuenschwander  7 , Hugo Vargas Filho  8 , Jorge Ilha Guimarães  9 , Jadelson Andrade  10 , Angelo Amato Vincenzo de Paola  11 , Marcus Vinicius Bolivar Malachias  12 , Luiz Alberto Piva E Mattos  9 , Dalton Bertolim Precoma  13 , Fernando Bacal  14 , Oscar Pereira Dutra  15
Affiliations

One year follow-up Assessment of Patients Included in the Brazilian Registry of Acute Coronary Syndromes (ACCEPT)

[Article in English, Portuguese]
Pedro Gabriel Melo de Barros E Silva et al. Arq Bras Cardiol. 2020 Jun.

Abstract

Background There is lack of prospective data on evolution within one year of acute coronary syndromes (ACS) in a representative population of Brazilian patients. Objectives To assess the prescription of evidence-based therapies, the incidence of severe outcomes and the predictors for these outcomes in a multicenter Brazilian registry of ACS patients. Methods The ACCEPT is a prospective observational study, which included patients hospitalized with a diagnostic of ACS in 47 Brazilian hospitals. The patients were followed for a 1 year and data were collected on the medical prescription and the occurrence of major cardiovascular events (cardiovascular mortality, reinfarction and cerebrovascular accident - CVA). Values of p < 0.05 were considered statistically significant. Results A total of 5,047 patients were included in this registry from August 2010 to April 2014. The diagnosis of ACS was confirmed in 4,782 patients (94.7%) and, among those, the most frequent diagnosis was ACS with ST segment elevation (35.8%). The rate of major cardiovascular events was 13.6 % within 1 year. Adherence to prescription of evidence-based therapy at admission was of 62.1%. Age, public service, acute myocardial infarction, CVA, renal failure, diabetes and quality of therapy were associated independently with the occurrence of major cardiovascular events. Conclusions During the one-year follow-up of the ACCEPT registry, more than 10% of the patients had major cardiovascular events and this rate ranged according with the quality of therapy. Strategies must be elaborated to improve the use of evidence-based therapies to minimize the cardiovascular events among the Brazilian population. (Arq Bras Cardiol. 2020; 114(6):995-1003).

PubMed Disclaimer

Conflict of interest statement

Potencial conflito de interesses

Pedro Gabriel Melo de Barros e Silva declara ter recebido honorários e bolsas de pesquisa da Pfizer, Roche Diagnostics e Bayer. Otavio Berwanger declara ter recebido bolsas de pesquisa e honorários pessoais da ASTRA Zeneca , Bayer e Boehringer Ingelheim; Bolsas da Amgen e Roche Diagnosis; e honorários pessoais da Novo Nordisk e Novartis.

Figures

Figura 1
Figura 1. - Adesão a terapias baseadas em evidência no seguimento de 1 ano. Para a comparação da continuidade da prescrição do medicamento nos seguimentos com a admissão, foi ajustado um modelo de Equações de Estimação Generalizada (EEG) para dados binários, para considerar a dependência entre as observações. ‡ Valor de p < 0,001; Comparação entre o seguimento e a admissão; † Valor de p < 0,01; Comparação entre o seguimento e a admissão; * Valor de p < 0,05; Comparação entre o seguimento e a admissão.
Figura 2
Figura 2. – Desfechos clínicos em 1 ano de acordo com o diagnóstico.
Figure 1
Figure 1. Adherence to evidence-based therapies in the first year of follow-up. To compare the continuity of medical prescription in follow-up with admission, a model of Generalized Estimating Equations (EEG) was adjusted for binary data, to take into consideration the dependence between observations. ‡ P-value < 0.001; Comparison between follow-up and admission; † P-value < 0.01; Comparison between follow-up and admission; * P value < 0.05; Comparison between follow-up and admission
Figure 2
Figure 2. – One-year clinical outcomes according with the diagnosis.
See this image and copyright information in PMC

References

    1. 1. World Health Organization (WHO).Cardiovascular Diseases. [Internet]. [Cited in 2019 Dec 12]Available from: http://www.who.int/cardiovascular_diseases/resources/atlas/en/ .
    1. 2. Brasil. Ministério da Saúde. [Cited in 2020 Jan 23]. Available from: http://tabnet.datasus.gov.br/cgi/deftohtm.exe?idb2011/c08.def
    1. 3. Kochanek KD, Xu JQ, Murphy SL, Minino AM, Kung HC. Deaths: preliminary data for 2009. Natl Vital Stat Rep.2011;59(4):1-51. - PubMed
    1. 4. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet. 1997;349(9064):1498-504. - PubMed
    1. 5. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, et al. Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119(3):480-6.. - PubMed

Publication types

MeSH terms