Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19
- PMID: 32639219
- PMCID: PMC7365835
- DOI: 10.1152/physrev.00019.2020
Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19
Keywords: COVID; elastase; neutrophil extracellular traps; plasmin; treatment.
Conflict of interest statement
No conflicts of interest, financial or otherwise, are declared by the author.
Comment on
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Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.Physiol Rev. 2020 Jul 1;100(3):1065-1075. doi: 10.1152/physrev.00013.2020. Epub 2020 Mar 27. Physiol Rev. 2020. PMID: 32216698 Free PMC article. Review.
References
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- Barbosa da Cruz D, Helms J, Aquino LR, Stiel L, Cougourdan L, Broussard C, Chafey P, Riès-Kautt M, Meziani F, Toti F, Gaussem P, Anglés-Cano E. DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma. FASEB J 33: 14270–14280, 2019. doi:10.1096/fj.201901363RRR. - DOI - PubMed
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