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Comment
. 2020 Jul 7;32(1):13-14.
doi: 10.1016/j.cmet.2020.06.014.

SGLT2 Inhibitor: Not a Traditional Diuretic for Heart Failure

Ashish Verma  1 , Ankit B Patel  2 , Sushrut S Waikar  3
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Free article
Comment

SGLT2 Inhibitor: Not a Traditional Diuretic for Heart Failure

Ashish Verma et al. Cell Metab. .
Free article

Abstract

Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human study investigating the diuretic effect of empagliflozin.

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  • Empagliflozin in Heart Failure: Diuretic and Cardiorenal Effects.
    Griffin M, Rao VS, Ivey-Miranda J, Fleming J, Mahoney D, Maulion C, Suda N, Siwakoti K, Ahmad T, Jacoby D, Riello R, Bellumkonda L, Cox Z, Collins S, Jeon S, Turner JM, Wilson FP, Butler J, Inzucchi SE, Testani JM. Griffin M, et al. Circulation. 2020 Sep 15;142(11):1028-1039. doi: 10.1161/CIRCULATIONAHA.120.045691. Epub 2020 May 15. Circulation. 2020. PMID: 32410463 Free PMC article. Clinical Trial.

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