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Comment
. 2020 Jul 7;32(1):8-10.
doi: 10.1016/j.cmet.2020.06.012.

Constitutional Thinness: tALKing the tALK or wALKing the wALK?

Y C Loraine Tung  1 , Stephen O'Rahilly  2
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Free article
Comment

Constitutional Thinness: tALKing the tALK or wALKing the wALK?

Y C Loraine Tung et al. Cell Metab. .
Free article

Abstract

In a recent issue of Cell, Orthofer et al. (2020) present a body of data from mice, flies, and humans that suggest (1) a physiological role for Alk in the normal control of energy balance across several species and (2) a possible contribution of genetic variants in or near ALK to the variability of adiposity in humans, more specifically at its lower end.

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Conflict of interest statement

Declaration of Interests S.O.R. undertakes remunerated consultancy work for Pfizer, AstraZeneca, GSK, and ERX Pharmaceuticals.

Comment on

  • Identification of ALK in Thinness.
    Orthofer M, Valsesia A, Mägi R, Wang QP, Kaczanowska J, Kozieradzki I, Leopoldi A, Cikes D, Zopf LM, Tretiakov EO, Demetz E, Hilbe R, Boehm A, Ticevic M, Nõukas M, Jais A, Spirk K, Clark T, Amann S, Lepamets M, Neumayr C, Arnold C, Dou Z, Kuhn V, Novatchkova M, Cronin SJF, Tietge UJF, Müller S, Pospisilik JA, Nagy V, Hui CC, Lazovic J, Esterbauer H, Hagelkruys A, Tancevski I, Kiefer FW, Harkany T, Haubensak W, Neely GG, Metspalu A, Hager J, Gheldof N, Penninger JM. Orthofer M, et al. Cell. 2020 Jun 11;181(6):1246-1262.e22. doi: 10.1016/j.cell.2020.04.034. Epub 2020 May 21. Cell. 2020. PMID: 32442405

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