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Randomized Controlled Trial
. 2020 Jul 6;17(13):4876.
doi: 10.3390/ijerph17134876.

A New Nasal Restriction Device Called FeelBreathe® Improves Breathing Patterns in Chronic Obstructive Pulmonary Disease Patients during Exercise

José L Gonzalez-Montesinos  1 , Aurelio Arnedillo  2   3 , Jorge R Fernandez-Santos  3   4 , Carmen Vaz-Pardal  5 , Pelayo A García  6 , José Castro-Piñero  3   4 , Jesús G Ponce-González  3   7
Affiliations
Randomized Controlled Trial

A New Nasal Restriction Device Called FeelBreathe® Improves Breathing Patterns in Chronic Obstructive Pulmonary Disease Patients during Exercise

José L Gonzalez-Montesinos et al. Int J Environ Res Public Health. .

Abstract

A device called FeelBreathe (FB)® was designed, developed, and patented for inspiratory muscle training. The main aim was to determine the acute responses on lung ventilation, gas exchange, and heart rate during exercise in patients with chronic obstructive pulmonary disease (COPD) with and without the use of FB. In this study, a randomized cross-over trial was performed with 18 men diagnosed with COPD (FEV1 between 30% and 70% of its predicted value). Each participant randomly conducted two trials with 30 min of rest between them with the same protocol on a treadmill for 10 min at a constant rate of 50% of VO2peak. Each test was performed randomly and in a crossover randomized design in two different conditions: (1) oronasal breathing; and (2) nasal breathing with FB (nasal ventilatory flow restriction device). It was observed that FB had positive effects on dynamic hyperinflation, breathing pattern, and breathing efficiency, with higher expiratory and inspiratory time. Despite these differences, blood oxygen saturation percentage, oxygen uptake, and heart rate showed a similar response for both conditions during exercise. The results suggest that exercise performed with FB improved ventilatory responses compared to the oronasal mode in COPD patients. This new tool could be used during most daily tasks and exercise programs.

Keywords: COPD; exercise; respiratory muscle training.

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Conflict of interest statement

The authors declare that there are no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Illustration of the design and analysis of the cross-over trial.
Figure 2
Figure 2
Bayesian functional ANOVA plots for FB > ONB group variables: inspiration time (Tin) (A), inspiratory time fraction (Tin/Tot ) (B), expiration time (Tex) (C), expiratory tidal volume (VTex); (D), inspiratory tidal volume (VTin) (E), fraction of expired carbon dioxide (FECO2) (F), end-tidal partial pressure of carbon dioxide (PETCO2) (G), oxygen uptake (VO2) (H), heart rate (HR) (I) and carbon dioxide production (VCO2) (J).
Figure 3
Figure 3
Bayesian functional ANOVA plots for ONB > FB group variables: respiratory quotient (RER) (A), breathing frequency (BF) (B), ventilatory equivalent ratio for carbon dioxide (EqCO2) (C), fraction of expired oxygen (FEO2) (D), expiratory time fraction (Tex/Tot), (E), end-tidal partial pressure of oxygen (PETO2) (F), minute ventilation (VE) (G), ventilatory equivalent ratio for carbon dioxide (EqCO2) (H) and dead space/tidal volume ratio (VD/VT) (I).
Figure 4
Figure 4
Percentage of change by participants and TE for FB > ONB group variables: Tin (A), Tin/Tot (B), Tex (C), VTex (D), VTin (E), FECO2 (F), PETCO2 (G), VO2 (H), HR (I) and VCO2 (J). Responders vs. non-responders on cardioventilatory variables with higher values in FB.
Figure 5
Figure 5
Percentage of change by participants and TE for ONB > FB group variables: RER (A), BF (B), EqO2 (C), FEO2 (D), Tex/Tot (E), PETO2(F), VE(G), EqCO2 (H) and VD/VT (I).
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