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. 2021 Jan;37(1):54-56.
doi: 10.1089/AID.2020.0022. Epub 2020 Aug 10.

Short Communication: HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences

Sello Given Mikasi  1 , Darren Isaacs  2 , George Mondinde Ikomey  3 , Henerico Shimba  1   4 , Ruben Cloete  3 , Graeme Brendon Jacobs  1
Affiliations

Short Communication: HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences

Sello Given Mikasi et al. AIDS Res Hum Retroviruses. 2021 Jan.

Abstract

HIV-1 integrase (IN) is a primary target for combination antiretroviral therapy. Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that 1.4% of sequence from treatment-naive patients had IN strand transfer inhibitor (INSTI) RAMs. These mutations confer resistance to raltegravir and elvitegravir. We also observed that 10.1% of the sequences have INSTI accessory RAMs. HIV-1 CRF02_AG was the predominant subtype (44.7%) in this study analyses. The occurrence of INSTI RAMs among the sequences at baseline needs to be monitored carefully.

Keywords: CRF02_AG; Cameroon; HIV-1; diversity; integrase; resistance.

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