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. 2020 Jul 8;17(1):96.
doi: 10.1186/s12985-020-01363-5.

The newly emerged COVID-19 disease: a systemic review

Endeshaw Chekol Abebe  1 , Tadesse Asmamaw Dejenie  2 , Mestet Yibeltal Shiferaw  3 , Tabarak Malik  4
Affiliations

The newly emerged COVID-19 disease: a systemic review

Endeshaw Chekol Abebe et al. Virol J. .

Abstract

Coronaviruses are large family-RNA viruses that belong to the order Nidovirales, family Coronaviridae, subfamily Coronavirinae. The novel COVID-19 infection, caused by a beta coronavirus called SARS-CoV-2, is a new outbreak that has been emerged in Wuhan, China in December 2019. The most common symptoms of COVID-19 are fever, cough, and dyspnea. As per the March 12, 2020, WHO report, more than 125,048 confirmed COVID-19 cases and over 4613 deaths have been identified in more than 117 countries. It is now regarded as a pandemic that seriously spread and attack the world. The primary means of transmission is person to person through droplets that occurred during coughing or sneezing, through personal contact (shaking hands), or by touching contaminated objects. So far, there is no effective therapy and vaccine available against this novel virus and therefore, only supportive care is used as the mainstay of management of patients with COVID-19. The mortality rate of COVID-19 is considerable. This work aimed to provide insight on the newly emerged COVID-19, in the hope to gain a better understanding on the general overview, epidemiology, transmission, clinical features, diagnosis, treatment, and clinical outcomes as well as the prevention and control of COVID-19.

Keywords: COVID-19; Outbreak; Pandemic; SARS-CoV-2.

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Conflict of interest statement

The authors have no competing interests.

Figures

Fig. 1
Fig. 1
Structure of novel coronavirus (SARS-CoV-2) (CREDIT: CDC/ Alissa Eckert, MS; Dan Higgins, MAM)
Fig. 2
Fig. 2
Distribution of reported confirmed COVID-19 cases by Countries, territories or areas as of 12 March 2020 [12]
Fig. 3
Fig. 3
Epidemic curve of confirmed COVID-19 cases reported outside of China (n = 44,067), by date of report and WHO region through 12 March 2020 [12]
Fig. 4
Fig. 4
Symptoms of COVID-19 (source: Mikael Häggström, M.D)
See this image and copyright information in PMC

References

    1. Woo PC, Huang Y, Lau SK, Yuen K-Y. Coronavirus genomics and bioinformatics analysis viruses. 2010;2(8):1804–20. - PMC - PubMed
    1. Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T. Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev. 2006;19:531–545. doi: 10.1128/CMR.00017-06. - DOI - PMC - PubMed
    1. de Wilde AHSE, Kikkert M, van Hemert MJ. Host factors in coronavirus replication. Curr Top Microbiol Immunol. 2018;419:1–42. - PMC - PubMed
    1. Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology. 2018;23(2):130–137. doi: 10.1111/resp.13196. - DOI - PMC - PubMed
    1. Peiris J, Lai S, Poon L, Guan Y, Yam L, Lim W, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319–1325. doi: 10.1016/S0140-6736(03)13077-2. - DOI - PMC - PubMed

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