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. 1988 Sep 15;254(3):885-90.
doi: 10.1042/bj2540885.

Citrobacter diversus ULA-27 beta-lactamases. Improved purification and general properties

G Amicosante  1 , A Oratore, N Franceschini, M Maccarrone, R Strom, M Galleni, J M Frère
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Citrobacter diversus ULA-27 beta-lactamases. Improved purification and general properties

G Amicosante et al. Biochem J. .

Abstract

Two chromosome-encoded beta-lactamases have been purified from Citrobacter diversus ULA-27. They exhibited slightly different isoelectric points (6.8 and 6.2) and very similar Mr values (congruent to 29,000). Their specificity spectrum was rather wide, since they hydrolysed some cephalosporins with kcat: values similar to those observed with the best penicillin substrates. Cloxacillin, methicillin and imipenem were hydrolysed very slowly. Hydrolysis of azthreonam could not be detected.

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