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Review
. 2020 Jul 8;11(7):512.
doi: 10.1038/s41419-020-2721-8.

Is hydroxychloroquine beneficial for COVID-19 patients?

Xing Li  1 , Ying Wang  2 , Patrizia Agostinis  3 , Arnold Rabson  4 , Gerry Melino  5 , Ernesto Carafoli  6 , Yufang Shi  7   8 , Erwei Sun  9   10
Affiliations
Review

Is hydroxychloroquine beneficial for COVID-19 patients?

Xing Li et al. Cell Death Dis. .

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world1-3, the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 20204. The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir5, to control the disease and halt the pandemic.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Hydroxychloroquine (HCQ) shows several potential effects against COVID-19 disease.
While HCQ is likely to have the ability to control the CRS, suppress hyperactive immune responses and subsequently promote tissue repair, which leads to significantly improved severe symptoms in late-stage of COVID-19.
Fig. 2
Fig. 2
Speculative dual role exerted by HCQ/CQ on calming tissue inflammation and protecting the endothelium against SARS-CoV-2 mediated injury.
See this image and copyright information in PMC

References

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