Reply to: In vivo quantification of mitochondrial membrane potential

Milica Momcilovic¹, Orian Shirihai^{2

3}, Michael P Murphy^{4

5}, Carla M Koehler^{6

3}, Saman Sadeghi⁷, David B Shackelford^{8

9}

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
² Department of Endocrinology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
³ Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
⁴ MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
⁵ Department of Medicine, University of Cambridge, Cambridge, UK.
⁶ Department of Chemistry and Biochemistry, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
⁷ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
⁸ Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA. dshackelford@mednet.ucla.edu.
⁹ Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA. dshackelford@mednet.ucla.edu.

Comment

Milica Momcilovic et al. Nature. 2020 Jul.

. 2020 Jul;583(7815):E19-E20.

doi: 10.1038/s41586-020-2367-9.

Milica Momcilovic¹, Orian Shirihai^{2

3}, Michael P Murphy^{4

5}, Carla M Koehler^{6

3}, Saman Sadeghi⁷, David B Shackelford^{8

9}

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
² Department of Endocrinology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
³ Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
⁴ MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
⁵ Department of Medicine, University of Cambridge, Cambridge, UK.
⁶ Department of Chemistry and Biochemistry, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
⁷ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
⁸ Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA. dshackelford@mednet.ucla.edu.
⁹ Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA. dshackelford@mednet.ucla.edu.

No abstract available

Comment on

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. Momcilovic M, et al. Nature. 2019 Nov;575(7782):380-384. doi: 10.1038/s41586-019-1715-0. Epub 2019 Oct 30. Nature. 2019. PMID: 31666695 Free PMC article.
In vivo quantification of mitochondrial membrane potential.
Alpert NM, Pelletier-Galarneau M, Petibon Y, Normandin MD, El Fakhri G. Alpert NM, et al. Nature. 2020 Jul;583(7815):E17-E18. doi: 10.1038/s41586-020-2366-x. Epub 2020 Jul 8. Nature. 2020. PMID: 32641811 Free PMC article. No abstract available.

1. Alpert, N. M., Pelletier-Galarneau, M., Petibon, Y., Normandin, M. D. & El Fakhri, G. In vivo quantification of mitochondrial membrane potential. Nature https://doi.org/10.1038/s41586-020-2366-x (2020).
1. Momcilovic, M. et al. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature 575, 380–384 (2019). - PubMed - PMC
1. Madar, I. et al. Characterization of membrane potential-dependent uptake of the novel PET tracer ¹⁸F-fluorobenzyl triphenylphosphonium cation. Eur. J. Nucl. Med. Mol. Imaging 34, 2057–2065 (2007). - PubMed
1. Madar, I. et al. Characterization of uptake of the new PET imaging compound ¹⁸F-fluorobenzyl triphenyl phosphonium in dog myocardium. J. Nucl. Med. 47, 1359–1366 (2006). - PubMed
1. Alpert, N. M. et al. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS One 13, e0190968 (2018). - PubMed - PMC