Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Sep;12(1):45-9.
doi: 10.1007/BF01805739.

EGF binding is quantitatively related to growth in node-positive breast cancer

E Spitzer  1 , K Koepke, D Kunde, R Grosse
Affiliations

EGF binding is quantitatively related to growth in node-positive breast cancer

E Spitzer et al. Breast Cancer Res Treat. 1988 Sep.

Abstract

Number of mitoses and EGF binding were determined in parallel in biopsies of 27 lymph-node positive and of 23 lymph-node negative breast cancer patients. For node-positive patients the parameters for cell growth and EGF binding were quantitatively correlated by the equation y = P3 + P1(1- exp(- P2x]. For node-negative cases neither the non-linear model nor the linear approximation described the data unambiguously. The results strongly suggest that in node-positive patients, growth of breast cancer is related to an EGF-dependent acceleration of cell division.

PubMed Disclaimer

References

    1. Lancet. 1985 Feb 16;1(8425):366-8 - PubMed
    1. Cancer Res. 1982 Nov;42(11):4394-8 - PubMed
    1. Cancer Res. 1984 Aug;44(8):3448-53 - PubMed
    1. Science. 1987 Jan 9;235(4785):177-82 - PubMed
    1. Cancer Res. 1987 Jan 15;47(2):403-6 - PubMed

Substances

LinkOut - more resources