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Review
. 2020 Jun;12(6):3217-3226.
doi: 10.21037/jtd-19-4171.

Pulmonary enteric adenocarcinoma: a literature review

Haiyan Li  1   2 , Wei Cao  1   2
Affiliations
Review

Pulmonary enteric adenocarcinoma: a literature review

Haiyan Li et al. J Thorac Dis. 2020 Jun.

Abstract

Pulmonary enteric adenocarcinoma (PEAC) is an extremely rare type of non-small cell lung cancer (NSCLC) with a histologic pattern that mimics metastatic colorectal cancer (MCC). The main clinical symptoms in PEAC patients are dyspnoea, coughing, hemoptysis, and chest and back pain. The first article about PEAC appeared in 1991 in the form of a case report. As a variant of invasive lung carcinoma, only a small number of case reports and clinical research studies have been carried out, and the only one guidance on diagnosis and treatment is the WHO Tumor Classification book. It is important for doctors to distinguish PEAC from MCC to extend survival time and improve the quality of life. We reviewed the existing literature regarding the diagnosis, treatment, and prognosis of PEAC to provide some valuable clinical references.

Keywords: Pulmonary carcinoma; diagnosis; enteric; prognosis; treatment.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jtd-19-4171). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Histomorphologic features of pulmonary enteric adenocarcinoma: (I) high columnar cells with eosinophilic cytoplasm that are arranged in irregular glandular lumens with central necrosis; (II) a tall or oval nucleus with pseudo-stratification. (H&E, ×200)
Figure 2
Figure 2
Survival data of patients with pulmonary enteric adenocarcinoma. Average survival time (AST) and medial survival time (MST) were stratified according to clinical stages (A). The distributions of alive and deceased patients were stratified according to clinical stages (B). A, Alive, D: Dead.
See this image and copyright information in PMC

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