Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec 5;241(1-2):6-10.
doi: 10.1016/0014-5793(88)81019-6.

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

P Kaur  1 , J Saklatvala
Affiliations
Free article

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

P Kaur et al. FEBS Lett. .
Free article

Abstract

Interleukin 1 (IL1) or tumour necrosis factor (TNF) stimulated phosphorylation of a triad of 27 kDa phosphoproteins (pI 6.0, 5.7 and 5.5) in human dermal fibroblasts. The change was dependent on the dose of cytokine in the range 0.1-20 ng, was detectable between 3 and 5 min after stimulation and was maximal by 10 min. The proteins were found in the cytosol after subcellular fractionation. The 32P was removed from them by alkali, indicating the presence of phosphoserine and/or phosphothreonine. The results suggest that early changes in serine/threonine protein kinase activity may be involved in responses of fibroblasts to IL1 and TNF.

PubMed Disclaimer

Publication types

LinkOut - more resources