Radiation Therapy and Mandibular Osteoradionecrosis: State of the Art

Abstract

Purpose of review: This article aims to provide an update on literature data related to mandibular osteoradionecrosis (MORN) secondary to the irradiation of the head and neck region.

Recent findings: Radiotherapy (RT) plays a crucial role in the contemporary management of head and neck cancer (HNC) patients and, despite intensity-modulated technique (IMRT), mandibular osteoradionecrosis (MORN) remains a significant RT-related complication. Based on its clinical manifestation, MORN can negatively affect patients' quality of life. Preventive interventions should be prioritized. This manuscript is expected to represent an opportunity to guide a clear proposal for clinical measures in the individual MORN situations.

Keywords: HBO; Head neck cancer; IMRT; Incidence; Osteoradionecrosis; Quality of life; Toxicity.