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. 2020 Sep;598(18):3803-3806.
doi: 10.1113/JP278219. Epub 2020 Jul 8.

CrossTalk proposal: Intramuscular lipid accumulation causes insulin resistance

Bret H Goodpaster  1
Affiliations
Free article

CrossTalk proposal: Intramuscular lipid accumulation causes insulin resistance

Bret H Goodpaster. J Physiol. 2020 Sep.
Free article
No abstract available

Keywords: insulin resistance; intramyocellular lipids; physical activity.

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References

    1. Adams JM 2nd, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, Sullards MC & Mandarino LJ (2004). Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 53, 25-31.
    1. Amati F, Dube JJ, Alvarez-Carnero E, Edreira MM, Chomentowski P, Coen PM, Switzer GE, Bickel PE, Stefanovic-Racic M, Toledo FG & Goodpaster BH (2011). Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes? Diabetes 60, 2588-2597.
    1. Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS & Perreault L (2016). Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans. Diabetologia 59, 785-798.
    1. Bergman BC, Hunerdosse DM, Kerege A, Playdon MC & Perreault L (2012). Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans. Diabetologia 55, 1140-1150.
    1. Bergman BC, Perreault L, Hunerdosse DM, Koehler MC, Samek AM & Eckel RH (2009). Intramuscular lipid metabolism in the insulin resistance of smoking. Diabetes 58, 2220-2227.

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