Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Sep;598(18):3813-3814.
doi: 10.1113/JP279715. Epub 2020 Jul 8.

Rebuttal from Marlou L. Dirks, Benjamin T. Wall and Francis B. Stephens

Affiliations
Free article
Comment

Rebuttal from Marlou L. Dirks, Benjamin T. Wall and Francis B. Stephens

Marlou L Dirks et al. J Physiol. 2020 Sep.
Free article
No abstract available

Keywords: insulin resistance; intramuscular lipid accumulation; muscle disuse.

PubMed Disclaimer

Comment on

References

    1. Appriou Z, Nay K, Pierre N, Saligaut D, Lefeuvre-Orfila L, Martin B, Cavey T, Ropert M, Loreal O, Rannou-Bekono F & Derbre F (2019). Skeletal muscle ceramides do not contribute to physical-inactivity-induced insulin resistance. Appl Physiol Nutr Metab 44, 1180-1188.
    1. Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH & van Loon LJ (2016). One week of bed rest leads to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal muscle lipid accumulation. Diabetes 65, 2862-2875.
    1. Goodpaster BH (2020). CrossTalk proposal: Intramuscular lipid accumulation causes insulin resistance. J Physiol 598, 3803-3806.
    1. Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ & Summers SA (2007). Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 5, 167-179.
    1. Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT; Lancet Physical Activity Series Working Group (2012). Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380, 219-229.

LinkOut - more resources