Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2020 Sep;48(7):938-945.
doi: 10.1111/ceo.13823. Epub 2020 Aug 4.

Multi-focal electro-retinogram response following sub-threshold nano-second laser intervention in age-related macular degeneration

Chi D Luu  1   2 , Galina Makeyeva  1 , Emily Caruso  1 , Elizabeth Baglin  1 , Pyrawy Sivarajah  1 , Zhichao Wu  1 , Robyn H Guymer  1   2
Affiliations
Randomized Controlled Trial

Multi-focal electro-retinogram response following sub-threshold nano-second laser intervention in age-related macular degeneration

Chi D Luu et al. Clin Exp Ophthalmol. 2020 Sep.

Abstract

Importance: The effect of sub-threshold nano-second laser (SNL) treatment on retinal function remains unknown.

Background: SNL treatment has been studied as a potential intervention in intermediate age-related macular degeneration (iAMD). This study investigated the longitudinal effect of SNL treatment on retinal function.

Design: This was a sub-study of the LEAD trial; a 36-month, multi-centre, randomized and sham-controlled trial.

Participants: Subjects with iAMD.

Methods: Eligible participants were assigned randomly to receive SNL or sham treatment to the study eye at 6-monthly visits. Multi-focal electro-retinography (mfERG) was performed at each study visit from a study site. The mfERG responses were grouped into three regions (central, middle and outer rings) and compared between the SNL and sham group.

Main outcome measures: mfERG P1 response amplitude and implicit time.

Results: Data were collected from 50 subjects (26 in the SNL group, 24 in the sham group). At baseline, the P1 amplitudes of both the study eyes and the fellow eyes were similar between the groups at all rings. In the sham group, the P1 amplitude gradually decreased over time (P < .05). In the SNL group, there was an improvement in P1 amplitude which became statistically significant at the 36-month visit, detected in both the treated and fellow eyes at the central (P = .005) and middle ring (P = .007) but not at the outer ring (P = .070). No difference in P1 implicit time detected between the groups (P > .05).

Conclusions and relevance: SNL treatment improved electro-physiological function. mfERG could be useful for monitoring AMD progression and evaluating the efficacy of SNL treatment.

Keywords: age-related macular degeneration (AMD); electro-retinogram; nanosecond laser treatment.

PubMed Disclaimer

References

REFERENCES

    1. Lek JJ, Brassington KH, Luu CD, et al. Subthreshold nanosecond laser intervention in intermediate age-related macular degeneration. Ophthalmol Retina. 2017;1:227-239.
    1. Guymer RH, Wu Z, Hodgson LAB, et al. Laser intervention in early stages of age-related macular degeneration study G. Subthreshold nanosecond laser intervention in age-related macular degeneration: the LEAD randomized controlled clinical trial. Ophthalmology. 2019;126:829-838.
    1. Wu Z, Luu CD, Hodgson LAB, et al. Secondary and exploratory outcomes of the subthreshold nanosecond laser intervention randomized trial in age-related macular degeneration: a LEAD study report. Ophthalmol Retina. 2019;3:1026-1034.
    1. Wu Z, Luu CD, Ayton LN, et al. Optical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degeneration. Ophthalmology. 2014;121:2415-2422.
    1. Jobling AI, Guymer RH, Vessey KA, et al. Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage. FASEB J. 2015;29:696-710.

Publication types

LinkOut - more resources