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. 1988 Dec 1;168(6):2385-9.
doi: 10.1084/jem.168.6.2385.

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells

P Rothman  1 , S Lutzker, W Cook, R Coffman, F W Alt
Affiliations

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells

P Rothman et al. J Exp Med. .

Abstract

To elucidate the mechanism of IL-4-induced enhancement of IgE and IgG1 production, murine splenic B cells and A-MuLV-transformed cells were cultured with LPS and IL-4 and assayed for epsilon and gamma 1 transcripts. Concomitant treatment with IL-4 and LPS induced expression of C epsilon transcripts in both normal and transformed cells. Expression of these truncated C epsilon transcripts preceded accumulation of normal epsilon mRNA in treated cells. Consistent data were obtained with respect to gamma 1 RNA expression. These results suggest that IL-4 can direct class switching in the context of a mechanism associated with differential expression of germline constant region genes.

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References

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