Ethacrynic Acid
- PMID: 32644414
- Bookshelf ID: NBK558988
Ethacrynic Acid
Excerpt
Ethacrynic acid is a medication used in the management and treatment of chronic heart failure. It is in the loop diuretic class of drugs. This activity describes the indications, action, and contraindications for ethacrynic acid as a valuable agent in managing fluid overload and CHF. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the healthcare team in the management of patients with CHF and related conditions.
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References
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- Cannon PJ, Kilcoyne MM. Ethacrynic acid and furosemide: renal pharmacology and clinical use. Prog Cardiovasc Dis. 1969 Jul;12(1):99-118. - PubMed
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- Mignani S, El Brahmi N, El Kazzouli S, Eloy L, Courilleau D, Caron J, Bousmina MM, Caminade AM, Cresteil T, Majoral JP. A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action. Eur J Med Chem. 2016 Oct 21;122:656-673. - PubMed
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